Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity

bra target=_blank rel=nofollow href=http://www.medworm.com/index.php?rid=3304586cid=c_1_31_ffid=33779url=http://dx.doi.org/10.1002%2Fjor.21103 Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity /abrMagnetic resonance imaging (MRI) of bone marrow edema (BME) has been found to be helpful in the diagnosis of back pain attributed to degenerative disk disease (DDD) and spondyloarthropathy (SA), but its interpretation is limited by a lack of knowledge of its nature and natural history. We assessed effects of compressive forces to mouse tail segments of WT and TNF-Tg mice with SA, via contrast enhanced-MRI and histology. Normalized marrow contrast enhancement (NMCE) of uninstrumented WT vertebrae significantly decrease, threefold (p 0.01) from 8 to 12 weeks of age, while the NMCE of TNF-Tg vertebrae remained elevated. Compressive loading (6× body weight) increased NMCE twofold (p 0.02) within 2 weeks in WT tails, which was equal to 6× loaded TNF-Tg tails within 4 weeks. Histology conf… br

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