Horizon Scanning: FDA panel supports extension to use of duloxetine (Cymbalta)

Horizon Scanning: FDA panel supports extension to use of duloxetine (Cymbalta)
Source: Reuters Area: News Reuters reports that a United States Food and Drug Administration (US FDA) advisory panel has supported an extension to the licensed indication for duloxetine (Cymbalta?) to include chronic back pain. The panel voted whether it effectively treated lower-back pain and osteoarthritis and voted 8-5 to approve its use for back pain, however, by a 4-9 vote they found there was insufficient data to support its use in osteoarthritis. The panellists also said there was not enough data to support a stronger 120mg dose over the current 60mg version.   The FDA will consider the advisory panel’s recommendation before making its final approval decision. Reuters notes that FDA officials said they were concerned about the impact of widening approval duloxetine, which…

A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain

A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain
The objective of this review was to determine the effectiveness of pharmacological interventions [i.e., non-steroid anti-inflammatory drugs (NSAIDs), muscle relaxants, antidepressants, and opioids] for non-specific chronic low-back pain (LBP). Existing Cochrane reviews for the four interventions were screened for studies fulfilling the inclusion criteria. Then, the literature searches were updated. Only randomized controlled trials on adults (≥18 years) with chronic (≥12 weeks) non-specific LBP and evaluation of at least one of the main clinically relevant outcome measures (pain, functional status, perceived recovery, or return to work) were included. The GRADE approach was used to determine the quality of evidence. A total of 17 randomized controlled trials was include…

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Positions For Curing Lower Back Pain

Positions For Curing Lower Back Pain
You may be suffering from a chronic lower backache. Exercise is necessary for relieving or preventing lower back pain that might occur to you. I would like to recommend some effective practices in exercising as the basic for those who suffer from lower backache. However, exercise should be done correctly to avoid back injuries.

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Pfizer has announced the suspension of its investigation of tanezumab for chronic lower back pain and painful diabetic peripheral neuropathy

Pfizer has announced the suspension of its investigation of tanezumab for chronic lower back pain and painful diabetic peripheral neuropathy
(Source: Reactions)

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Diagnostic Nerve Blocks Costly — And Controversial (CME/CE)

Diagnostic Nerve Blocks Costly — And Controversial (CME/CE)
While some guidelines recommend two diagnostic nerve blocks before radiofrequency treatment for chronic low back pain, a randomized trial showed greater success without use of the prior blocks. (Source: MedPage Today State Required CME)

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A little adversity bodes well for those with chronic back pain

A little adversity bodes well for those with chronic back pain
(University at Buffalo) A new study by researchers at the University at Buffalo and the University of California, Irvine, to be published in the September issue of the journal Pain, reveals that, for people with chronic back pain, having a little adversity in your life can be protective and beneficial. (Source: EurekAlert! - Medicine and Health)

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Change Your Attitude, Relieve Your Back Pain

Change Your Attitude, Relieve Your Back Pain
(Ivanhoe Newswire) — Ten percent of those with lower back pain never feel relief and often experience disability as a result. New research now shows chronic sufferers’ beliefs and behaviors towards their disorder have a greater impact on their disability than the intensity of their pain. (Source: Medical Headlines From Ivanhoe.com)

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Common Facts About Back Pain and Ideas For Prevention

Common Facts About Back Pain and Ideas For Prevention
If you are one of the millions of people who suffer chronic back pain you may feel as though you’ll never find relief. Whether you have lower or upper pain there are treatment options available to you.

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Randomised controlled trial of integrated care to reduce disability from chronic low back pain in working and private life. Lambeek LC, van Mechelen W, Knol DL, Loisel P, Anema JR. BMJ 2010;340:c1035

Randomised controlled trial of integrated care to reduce disability from chronic low back pain in working and private life. Lambeek LC, van Mechelen W, Knol DL, Loisel P, Anema JR. BMJ 2010;340:c1035
OBJECTIVE: To evaluate the effectiveness of an integrated care programme, combining a patient directed and a workplace directed intervention, for patients with chronic low back pain. (Source: The Spine Journal)

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Pfizer suspends tanezumab osteoarthritis clinical trial programme

Pfizer suspends tanezumab osteoarthritis clinical trial programme
Source: Pfizer Area: News Pfizer Inc. has announced the suspension of the osteoarthritis clinical programme for its investigational compound tanezumab following a request by the FDA. The worldwide suspension follows a small number of reports of patients on tanezumab experiencing a worsening of osteoarthritis leading to joint replacement. To date, this adverse event has not been observed in non-osteoarthritis patient populations taking the drug. The FDA has asked the company to present its assessment of the potential implications of this adverse event for the other tanezumab clinical programmes involving non-osteoarthritis patients (cancer pain, interstitial cystitis, chronic low back pain and painful diabetic peripheral neuropathy). (Source: NeLM - News)

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