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Back pain startup SI-Bone gets $10.6M

August 30, 2010 by admin · Leave a Comment 

Back pain startup SI-Bone gets $10.6M
SI-Bone Inc., a maker of low-invasive surgical technology for use on patients with lower back pain, has raised $10.6 million of a total $11 million equity round of funding, according to forms filed Aug. 17 with the U.S. Securities and Exchange Commission. (Source: bizjournals.com Health Care:Health Insurance headlines)

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Pfizer suspends tanezumab osteoarthritis clinical trial programme

August 2, 2010 by admin · Leave a Comment 

Pfizer suspends tanezumab osteoarthritis clinical trial programme
Source: Pfizer Area: News Pfizer Inc. has announced the suspension of the osteoarthritis clinical programme for its investigational compound tanezumab following a request by the FDA. The worldwide suspension follows a small number of reports of patients on tanezumab experiencing a worsening of osteoarthritis leading to joint replacement. To date, this adverse event has not been observed in non-osteoarthritis patient populations taking the drug. The FDA has asked the company to present its assessment of the potential implications of this adverse event for the other tanezumab clinical programmes involving non-osteoarthritis patients (cancer pain, interstitial cystitis, chronic low back pain and painful diabetic peripheral neuropathy). (Source: NeLM - News)

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12. Pain Originating from the Lumbar Facet Joints

August 1, 2010 by admin · Leave a Comment 

12. Pain Originating from the Lumbar Facet Joints
Although the existence of a “facet syndrome” had long been questioned, it is now generally accepted as a clinical entity. Depending on the diagnostic criteria, the zygapophysial joints account for between 5% and 15% of cases of chronic, axial low back pain. Most commonly, facetogenic pain is the result of repetitive stress and/or cumulative low-level trauma, leading to inflammation and stretching of the joint capsule. The most frequent complaint is axial low back pain with referred pain perceived in the flank, hip, and thigh. No physical examination findings are pathognomonic for diagnosis. The strongest indicator for lumbar facet pain is pain reduction after anesthetic blocks of the rami mediales (medial branches) of the rami dorsales that innervate the facet joints. Because false-positiv…

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Burden of childhood-onset arthritis

July 28, 2010 by admin · Leave a Comment 

Burden of childhood-onset arthritis
Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated morbidity, and life-long disability and risk for emotional and social dysfunction. In this article we will review the burden of juvenile arthritis for the patient and society and focus on the following areas: patient disability; visual outcome; other medical complications; physical activity; impact on HRQOL; emotional impact; pain and …

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Back Pain Information

May 2, 2010 by admin · Leave a Comment 

Back Pain Information
Dorsalgia is another term for back pain or back suffering. Nerves, muscles, bones, joints or other structure in the spine are the locations where the pain usually originates.

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Cymbalta(R) Significantly Reduced Chronic Low Back Pain In New Study

February 10, 2010 by admin · Leave a Comment 

Cymbalta(R) Significantly Reduced Chronic Low Back Pain In New Study
In a new study, 60 mg of Cymbalta(R) (duloxetine HCl) taken once daily significantly reduced chronic low back pain, as measured by the Brief Pain Inventory (BPI) average pain rating, compared with placebo.(1) The data were presented at the annual meeting of the American Academy of Pain Medicine (AAPM) in San Antonio, Texas… (Source: Pharma Industry News From Medical News Today)

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‘Minor Ailments’ Not Always Minor, Australia

February 6, 2010 by admin · Leave a Comment 

‘Minor Ailments’ Not Always Minor, Australia
AMA Vice President, Dr Steve Hambleton, said today that calls by the self-medication industry for pharmacists to treat so-called ‘minor ailments’ such as coughs, colds, sore throats and back pain instead of doctors could put people with these ailments at risk of more serious health problems. Dr Hambleton said that minor ailments are not always minor. “Respiratory tract infections and back pain are often precursors to more serious conditions and require proper diagnosis,” Dr Hambleton said. “Doctors are skilled in diagnosis, pharmacists aren’t… (Source: Health News from Medical News Today)

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Baby’s Giving Mom a Pain in the Back

January 25, 2010 by admin · Leave a Comment 

Baby’s Giving Mom a Pain in the Back
t is normal for expecting moms to experience back pain. When you are pregnant, you gain lots of weight fast, your way of walking changes, and your hormones relax the ligaments and joints in your body.

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Whiplash injury: 2% are permanently disabled

January 5, 2010 by admin · Leave a Comment 

Whiplash injury: 2% are permanently disabled
Whiplash and whiplash-associated disorders (WAD) represent a range of injuries to the neck caused by or related to a sudden distortion of the neck. Whiplash is commonly associated with motor vehicle accidents, usually when the vehicle has been hit in the rear; however, the injury can be sustained in many other ways, including falls from bicycles or horses.Most cases of whiplash injury occur as the result of rear-end vehicle collisions at speeds of less than 14 mph. Patients present with:- neck pain and stiffness- occipital headache- thoracolumbar back pain and upper-limb pain- paraesthesiaOver 66% make a full recovery and 2% are permanently disabled.References:Whiplash injury. G. Bannister et al. Journal of Bone and Joint Surgery - British Volume, Vol 91-B, Issue 7, 845-850. doi: 10.1302/0…

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Possible nociceptive structures in the sacroiliac joint cartilage: An immunohistochemical study

January 2, 2010 by admin · Leave a Comment 

Possible nociceptive structures in the sacroiliac joint cartilage: An immunohistochemical study
The sacroiliac joint (SI joint) is a known source of low back pain. In the absence of validated physical signs and imaging studies, the diagnosis of SI joint pain can be secured by positive response to SI joint intra-articular infiltration with local anesthetics. The current anatomical and histological knowledge concerning intra-articular structures of the sacroiliac joint is insufficient to explain the efficacy of this infiltration. Consequently, this study was undertaken to detect the intra-articular presence of substance P and calcitonin gene-related peptide (CGRP) positive nerve fibers, providing indirect evidence of nociceptive innervation of the SI joint. Free-floating sections, obtained from iliac and sacral cartilage and subchondral bone of the SI joint and adjacent ligamentous tis…

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