Pharmacology of steroids used during epidural steroid injections
November 27, 2009 by admin
Pharmacology of steroids used during epidural steroid injections
Steroids are well recognized for their excellent anti-inflammatory actions. After first steroid was used to treat painful arthritis, it became apparent that epidural steroid administration may be effective for management of sciatica pain and low back pain. Later on, other types of neural blockade techniques, such as facet joint injections, were described as the treatment option for low back pain. The most commonly used steroid preparations for the neuraxial blockade are methylprednisolone acetate (Depo-Medrol, Pfizer, New York, NY), triamcinolone acetonide and diacetate (Kenalog, Bristol-Myers Squibb, Princeton, NJ), betamethasone acetate (Celestone, Schering-Plough Corporation, Kenilworth, NJ), and dexamethasone (Decadron, Merch & Company Inc, West Point, PA). Glucocorticoids are postulat…
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